Bill Jackson serves as President and Chief Scientist of Base Pair Biotechnologies. Prior to formal spinout of aptamer discovery services under Base Pair, Bill guided numerous aptamer selections on both a service basis and for active research projects at parent company, BioTex, Inc. (also in Houston,TX).
Dr. Jackson is still partially employed by BioTex where he serves as a Senior Scientist on a number of synergistic research projects involving aptamers and biosensing. He joined BioTex in 2005 while concurrently finishing his Ph.D. in Chemical Engineering at nearby University of Houston. He has the somewhat rare distinction of funding his own doctoral dissertation serving as Principal Investigator on a NASA-funded SBIR grant. At the University of Houston, his research focused primarily on the development of novel nucleic acid diagnostics using both mass spectrometry and nucleic acid microarrays. Since that time, Dr. Jackson has served as Principal Investigator on 11+ SBIR grants and co-investigator on several more. He has been issued 4 U.S.patents with 10+ pending.
In previous employment Bill has been involved in the development of a wide variety of analytical chemistry equipment including instruments still in service aboard the International Space Station. Dr. Jackson received the B.S. in biomedical engineering from Texas A&M University in 1997 and a B.A. in Spanish in 1998.
In 2010 Dr. Jackson co-authored, “Nucleic Acid Aptamers for Diagnostics and Therapeutics: Global Markets” for BCC Research.
More about Dr. Jackson, including prior employment and publications can be found here:
Lisa Thurston oversees Base Pair Biotechnologies’ global strategic and business development emerging corporate and services offerings initiatives. She brings extensive experience in account management, business collaborations, and successfully nurturing embryonic businesses from early stage inception, leveraging many years of laboratory research in complementary areas as well. She focuses on Base Pair Bio’s market development, strategic planning, and operations management and works to identify organizational development opportunities for growth and optimization. In addition, Lisa manages the customer facing aspects with direct input into non-customer facing organizations that are responsible for the entire Base Pair Biotechnologies portfolio.
Lisa received her B.S. and M.S. in Biology from The University of Massachusetts at Lowell where she also serves on the Advisory Board for the Biology Department. Lisa received her M.B.A. from Bentley University in Operations and Management.
More about Ms. Thurston, including prior employment and publications can be found here:
Mark Morris’ doctoral training was in Biochemistry at Kent State University where he primarily studied the translational regulation of mRNA by G-quadraplex structures (a common motif in aptamers and riboswitches). During this work Mark discovered that a G-quadruplex sequence located in the 5′-UTR of the MT3-MMP gene forms an ultra-stable intramolecular G-quadruplex that inhibits translation in eukaryotic cells. This work required significant RNA engineering efforts as well as directed aptamer selection and ultimately resulted in several high-impact publications in which Mark was first author. Mark also has an M.S. degree in Chemistry from SUNY-Buffalo and is adept in numerous bio- and chemical analytical techniques. Mark is responsible for the day-to-day project management and aptamer selections at Base Pair and reports directly to Dr. Jackson.
More about Dr. Morris, including prior employment and publications can be found here:
Yogesh Sanghvi, Ph.D., Consultant, nucleic acid and general chemistry.
Dr. Yogesh Sanghvi is a respected member of the nucleic acid research community, having served in various leadership roles for over 14 years at Isis Pharmaceuticals. Dr. Sanghvi’s last role at Isis was Executive Director of Developmental Chemistry. Since 2003, he has served as founder and President of Rasayan, Inc. (Encinitas, CA). Rasayan specializes in consulting and supply-chain management for nucleosides, nucleotides and oligonucleotides related products for the pharmaceutical industry, research laboratories and academia. For Base Pair, Dr. Sanghvi provides expert consultation in general organic chemistry supporting, for example, our many projects involving aptamers to small molecule targets. Finally, Yogesh brings his expertise to bear on scaled-up delivery of both natural and non-natural oligonucleotide chemistries to our customers with a constant mind on both quality and total cost considerations.
Other Principals at Base Pair:
Base Pair Biotechnologies, Inc. is currently a privately held company in Houston, Texas. Through sister companies, BioTex, Inc. and Visualase, Inc., Base Pair has access to considerable additional technical and business leadership experience (see below).
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Ashok Gowda, Ph.D. – Board Member
Dr. Gowda has over 14 years experience in directing medical and biotechnology development and has contributed to the successful founding and growth of BioTex, Inc. on both the scientific and management fronts. As CEO of BioTex, Dr. Gowda ensures that a pipeline of novel early stage development projects are managed appropriately including maintaining a strong intellectual property program and appropriate personnel and financial resources. Dr. Gowda also serves as Chief Operating Officer for Visualase, Inc, a BioTex spin-out company, which under SBIR funding has successfully driven a number of medical devices from conception to commercialization. Dr. Gowda was successful in helping to raise private and institutional equity and bringing in additional management and commercial expertise with a focus on commercialization efforts.
Dr. Gowda received his B.E. degree in Biomedical Engineering from Vanderbilt University in 1991 and the M.S. and Ph.D. degrees in Bioengineering from Texas A&M University in 1998.
Roger McNichols, Ph.D. – Board Member
Since co-founding BioTex in 1997, Dr. McNichols has served in both an executive and scientific capacity to drive robust growth of the technology and intellectual property portfolios within the company. Dr. McNichols is responsible for managing all scientific and engineering development at BioTex, and has a wealth of project management experience including service as a PI or co-PI on over 30 funded federal research projects. Dr. McNichols was the principal inventor and developer of the Visualase technology which formed the basis for a successful commercial spin-out company (Visualase, Inc.) where he also continues to serve as the Chief Technology Officer. Recently, Dr. McNichols has supported several genomics-based projects for Dr. Jackson, and the two have several joint publications in molecular diagnostics and biology.
Dr. McNichols received a Bachelor’s Degree in Electrical Engineering from the Ohio State University in 1992 and the Ph.D. degree in Biomedical Engineering from Texas A&M University in 1998. He has a strong background in the life sciences including a year of formal training in medical school.