Aptamers to Dengue Virus Type 2 NS1 Glycoprotein
Dengue virus is the cause of dengue fever. It is a mosquito-borne single positive-stranded RNA virus. There are four antigenically related, but distinct, dengue virus serotypes (DEN-1, DEN-2, DEN-3 and DEN-4). The NS1 protein is detectable in human serum of infected individuals. It is a 50 kDa non-structural glycoprotein that interacts with intracellular membranes and the cell surface. The NS1 protein appears to utilize normal lipid metabolic pathways to affect the complement system and promote infection.
The Base Pair Dengue aptamers are 32-nucleotide natural DNA aptamers selected for binding to the DEN-2 NS1 glycoprotein.
Gutsche, I. et al. (2011) Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein. PNAS. 108(19):8003-08.