New Grant Award for Discovery of Aptamers to Canine Oncology Biomarkers

Comparative oncology is the study of naturally-occurring cancer in animals to identify treatments that can be applied to humans. Many types of cancer, including several types that are identical to human cancer, are very common in dogs. Clinicians are learning that curing cancer in dogs can frequently result in effective cures for humans. Read more about canine cancer research.

Base Pair Biotechnologies has recently been awarded an NIH SBIR Contract entitled, “Development and Validation of Non-Mouse Reagents to Enable Preclinical Development of Novel Therapeutics”.

“It is increasingly understood that the canine model is a much higher fidelity representation for studying human cancer than smaller mammals. Using our patented ability to multiplex aptamer selection, Base Pair is in a unique position to rapidly discover affinity reagents to important canine cancer biomarkers. These new reagents should quickly prove useful in the study of cancer in dogs and, ultimately, translation of new therapeutics from preclinical trials to the treatment of human cancers.” – Dr. Bill Jackson, Founder and Chief Scientist, Base Pair Biotechnologies

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New Grant Award for Detection of Synthetic Opioids on Surfaces

According to the National Institute on Drug Abuse, overdoses from synthetic opioids, including fentanyl, spiked to almost 30,000 in 2017, up from 5,000 just three years prior. As the availability and use of powerful synthetic opioids escalates, first responders, law enforcement, medical personnel, remediation workers and forensic laboratory personnel are increasingly at risk. Base Pair Biotechnologies has been awarded a grant from the CDC to develop aptamers and lateral flow assays (simple strip tests) for the rapid detection of several synthetical opioids on surfaces. Detection of the presence of powerful opioids can reduce accidental exposure, improve remediation efforts, and confirm required treatment in response to accidental exposure. The grant award titled “Identification and/or Creation of Aptamers with Affinity to Fentanyl, Carfentanil, Acetyl Fentanyl, and Naloxone: Development of Prototype Lateral Flow Assays” is focused on field-based detection of several potent synthetic opioids. Read about other opioid aptamers developed at Base Pair. ASK ABOUT OPIOID APTAMERS

New Base Pair Publication: Inhibition of Vitamin C Oxidation by DNA Aptamers

Base Pair has discovered an aptamer that inhibits the oxidation of vitamin C. The initial aptamer reduced vitamin C oxidation 2-fold to 4-fold under oxidizing conditions. Preliminary results suggest the potential for aptamers as stabilizers of key ingredients in beverages, nutritional supplements, and cosmetics. View Article PDF

DNA Aptamers or RNA Aptamers?

A growing number of researchers are turning to custom aptamer selection for detection of difficult targets, including small molecules and toxic compounds, and selective detection of highly similar compounds, but is it better to select for DNA aptamers or RNA Aptamers? Visit DNA Aptamers or RNA Aptamers? to learn more.

Enhancing Aptamer Stability

Stability can be of great concern when designing reagents for in vivo applications or blood-based tests. Several aptamer modifications have proven successful in extending aptamer half-life. Visit Enhancing Aptamer Stability to learn more.

The Importance of Negative Aptamer Selection

While the target is a critical component of any aptamer selection, negative targets, or molecules the aptamer SHOULD NOT bind, can be critically important as well. Incorporating negative targets into the selection design can generate more selective aptamers more quickly. Visit the Negative Aptamer Selection page to learn more.

Aptamer Applications Webinar

Bill Jackson Ph.D. discusses aptamers and aptamer selection, the differences between aptamers and antibodies, aptamer advantages, aptamer development at Base Pair, and data for a wide range of aptamer-based applications in research, diagnostics, and therapeutics. 

Aptamer Surveys

Thank you to our recent Base Pair Biotechnologies Aptamer Survey winners from: Philadelphia, PA, USA San Diego, CA, USA Ontario, Canada

Apt Aptamer Technology Article

Bill Jackson Ph.D. and CSO at Base Pair Biotechnologies was interviewed for an article in International Innovation, Health Partnership, the leading global dissemination resource for the wider scientific, technology and research communities.  The article entitled “Apt Aptamer Technology” on page 100 of the August 2013 issue explores how aptamers are proving an effective alternative to conventional immunization and information on Base Pair’s patented approach to custom aptamer development.

Aptamer Handling & Storage

Specific buffers and re-folding procedures are recommended for optimal aptamerAptamer Handling Guide stability and performance. Download the Aptamer Best Practices: Handling & Storage Guide to learn more.

 

Catalog Aptamer Information

alpha B Crystallin (Human) Aptamer, ATW0003  Data Sheet  Product Page

Ampicillin Aptamer, ATW0001  Data Sheet   Product Page

Botulinum Neurotoxin (BoNT-B), ATW0075  Data Sheet  Product Page

Brain Natriuretic Peptide, BNP-32 (Human) Aptamer, ATW0079  Data Sheet  Product Page Brain Natriuretic Peptide, BNP-32 (Human) Aptamer, ATW0080  Data Sheet  Product Page

Cancer Antigen 125, CA-125 (Human) Aptamer, ATW0055  Data Sheet  Product Page

CD8 (Murine) Aptamer, ATW0028  Data Sheet  Product Page

CD19 (Human) Aptamer, ATW0013  Data Sheet  Product Page CD19 (Human) Aptamer, ATW0016  Data Sheet  Product Page CD19 (Human) Aptamer, ATW0019  Data Sheet  Product Page

CD20 (Human) Aptamer, ATW0061  Data Sheet  Product Page

CD45 (Human) Aptamer, ATW0081  Data Sheet  Product Page

CD63 (Human) Aptamer, ATW0056  Data Sheet  Product Page CD63 (Human) Aptamer, ATW0057  Data Sheet  Product Page

CEACAM1, CD66a (Human) Aptamer, ATW0051  Data Sheet  Product Page CEACAM1, CD66a (Human) Aptamer, ATW0052  Data Sheet  Product Page

Chloride Intracellular Channel 1, CLIC-1 (Human) Aptamer, ATW0046  Data Sheet  Product Page

Chorionic Gonadotropin, hCG (Human) Aptamer, ATW0014  Data Sheet  Product Page

Citrulline Aptamer, ATW0100, Data Sheet  Product Page

Collagen (Human) Aptamer, ATW0002  Data Sheet  Product Page

Cytokeratin-19, CK-19 (Human) Aptamer, ATW0053  Data Sheet  Product Page Cytokeratin-19, CK-19 (Human) Aptamer, ATW0054  Data Sheet  Product Page

Cytomegalovirus pp65 (CMV pp65) Protein, ATW0043  Data Sheet  Product Page Cytomegalovirus pp65 (CMV pp65) Protein, ATW0044  Data Sheet  Product Page Cytomegalovirus pp65 (CMV pp65) Protein, ATW0058  Data Sheet  Product Page

Dengue Type 2 NS1 Viral Protein Aptamer, ATW0004  Data Sheet  Product Page Dengue Type 2 NS1 Viral Protein Aptamer, ATW0005  Data Sheet  Product Page Dengue Type 2 NS1 Viral Protein Aptamer, ATW0064  Data Sheet  Product Page

Epinephrine/Norepinephrine Aptamer, ATW0066  Data Sheet  Product Page

Epirubicin Aptamer, ATW0006  Data Sheet  Product Page

Erk1 (aa190-208) Aptamer, ATW0091  Data Sheet  Product Page pErk1, Thr202 (aa190-208) Aptamer, ATW0092  Data Sheet  Product Page pErk2, Thr183 (aa171-189) Aptamer, ATW0090  Data Sheet  Product Page

Fibrinogen (Human) Aptamer, ATW0007  Data Sheet  Product Page

Fibronectin (Human, Bovine) Aptamer, ATW0008  Data Sheet  Product Page

Gamma Synuclein (Human) Aptamer, ATW0048  Data Sheet  Product Page

Glutathione S-Transferase pi 1, GDTP1, (Human) Aptamer, ATW0050  Data Sheet  Product Page

Granzyme B (Human) Aptamer, ATW0047  Data Sheet  Product Page

Heat Shock Protein 27, Hsp27 (Human) Aptamer, ATW0009  Data Sheet  Product Page

Hemoglobin (Human) Aptamer, ATW0010  Data Sheet  Product Page Hemoglobin (Human) Aptamer, ATW0011  Data Sheet  Product Page

Heparin Sulfate, HS (Murine) Aptamer, ATW0012  Data Sheet  Product Page

Human Serum Albumin, HSA, Aptamer, ATW0015  Data Sheet  Product Page Human Serum Albumin, HSA, Aptamer, ATW0085  Data Sheet  Product Page Human Serum Albumin, HSA, Aptamer, ATW0086  Data Sheet  Product Page

Immunoglobulin M, IgM Aptamer, ATW0021 Data Sheet  Product Page

IFN gamma (Bovine) Aptamer, ATW0036  Data Sheet  Product Page

IL-6 (Human) Aptamer, ATW0035  Data Sheet  Product Page IL-6 (Murine) Aptamer, ATW0077  Data Sheet  Product Page IL-6 (Murine) Aptamer, ATW0082  Data Sheet  Product Page IL-6 (Murine) Aptamer, ATW0083  Data Sheet  Product Page

IL-7 (Human) Aptamer, ATW0023  Data Sheet  Product Page

IL-10 (Human) Aptamer, ATW0037  Data Sheet  Product Page

IL-18 (Human) Aptamer, ATW0022  Data Sheet  Product Page

Laminin (Murine) Aptamer, ATW0024  Data Sheet  Product Page

Latency Associated Peptide, LAP (Human), ATW0025  Data Sheet  Product Page Latency Associated Peptide, LAP (Human), ATW0026  Data Sheet  Product Page

mCherry Red Fluorescent Protein, ATW0059 Data Sheet  Product Page

MMP-3 (Murine) Aptamer, ATW0062  Data Sheet  Product Page MMP-3 (Murine) Aptamer, ATW0063  Data Sheet  Product Page

p24, HIV-1 Aptamer, ATW0038  Data Sheet  Product Page p24, HIV-1 Aptamer, ATW0041  Data Sheet  Product Page

Penicillin-binding-protein 2a, PBP2a, from MRSA, ATW0032  Data Sheet  Product Page Penicillin-binding-protein 2a, PBP2a, from MRSA, ATW0033  Data Sheet  Product Page 

Peroxiredoxin-4 (Human) Aptamer, ATW0029  Data Sheet  Product Page

Procalcitonin (Human) Aptamer, ATW0060  Data Sheet  Product Page

Protein A Aptamer, ATW0069  Data Sheet  Product Page

Ribonucleotide Reductase M2 Polypeptide, RRM2 (Human) Aptamer, ATW0030  Data Sheet  Product Page

Tenofovir Aptamer, ATW0067  Data Sheet  Product Page

Tetanus Toxoid Aptamer, ATW0073  Data Sheet  Product Page Tetanus Toxoid Aptamer, ATW0074  Data Sheet  Product Page

Tetracycline Aptamer, ATW0031  Data Sheet  Product Page