New Grant Award for Discovery of Aptamers to Canine Oncology Biomarkers
Comparative oncology is the study of naturally-occurring cancer in animals to identify treatments that can be applied to humans. Many types of cancer, including several types that are identical to human cancer, are very common in dogs. Clinicians are learning that curing cancer in dogs can frequently result in effective cures for humans. Read more about canine cancer research. Base Pair Biotechnologies has recently been awarded an NIH SBIR Contract entitled, “Development and Validation of Non-Mouse Reagents to Enable Preclinical Development of Novel Therapeutics”. “It is increasingly understood that the canine model is a much higher fidelity representation for studying human cancer than smaller mammals. Using our patented ability to multiplex aptamer selection, Base Pair is in a unique position to rapidly discover affinity reagents to important canine cancer biomarkers. These new reagents should quickly prove useful in the study of cancer in dogs and, ultimately, translation of new therapeutics from preclinical trials to the treatment of human cancers.” – Dr. Bill Jackson, Founder and Chief Scientist, Base Pair Biotechnologies
New Base Pair Publication: Inhibition of Vitamin C Oxidation by DNA Aptamers
Base Pair has discovered an aptamer that inhibits the oxidation of vitamin C. The initial aptamer reduced vitamin C oxidation 2-fold to 4-fold under oxidizing conditions. Preliminary results suggest the potential for aptamers as stabilizers of key ingredients in beverages, nutritional supplements, and cosmetics. View Article PDF
DNA Aptamers or RNA Aptamers?
A growing number of researchers are turning to custom aptamer selection for detection of difficult targets, including small molecules and toxic compounds, and selective detection of highly similar compounds, but is it better to select for DNA aptamers or RNA Aptamers? Visit DNA Aptamers or RNA Aptamers? to learn more.
Aptamer Applications Webinar
Bill Jackson Ph.D. discusses aptamers and aptamer selection, the differences between aptamers and antibodies, aptamer advantages, aptamer development at Base Pair, and data for a wide range of aptamer-based applications in research, diagnostics, and therapeutics.
Thank you to our recent Base Pair Biotechnologies Aptamer Survey winners from: Philadelphia, PA, USA San Diego, CA, USA Ontario, Canada
Apt Aptamer Technology Article
Bill Jackson Ph.D. and CSO at Base Pair Biotechnologies was interviewed for an article in International Innovation, Health Partnership, the leading global dissemination resource for the wider scientific, technology and research communities. The article entitled “Apt Aptamer Technology” on page 100 of the August 2013 issue explores how aptamers are proving an effective alternative to conventional immunization and information on Base Pair’s patented approach to custom aptamer development.
Aptamer Handling & Storage
Specific buffers and re-folding procedures are recommended for optimal aptamer stability and performance. Download the Aptamer Best Practices: Handling & Storage Guide to learn more.
Catalog Aptamer Information
Brain Natriuretic Peptide, BNP-32 (Human) Aptamer, ATW0079 Data Sheet Product Page Brain Natriuretic Peptide, BNP-32 (Human) Aptamer, ATW0080 Data Sheet Product Page
CD19 (Human) Aptamer, ATW0013 Data Sheet Product Page CD19 (Human) Aptamer, ATW0016 Data Sheet Product Page CD19 (Human) Aptamer, ATW0019 Data Sheet Product Page
CD63 (Human) Aptamer, ATW0056 Data Sheet Product Page CD63 (Human) Aptamer, ATW0057 Data Sheet Product Page
Cytomegalovirus pp65 (CMV pp65) Protein, ATW0043 Data Sheet Product Page Cytomegalovirus pp65 (CMV pp65) Protein, ATW0044 Data Sheet Product Page Cytomegalovirus pp65 (CMV pp65) Aptamer Information
Dengue Type 2 NS1 Viral Protein Aptamer, ATW0004 Data Sheet Product Page Dengue Virus Aptamer ATW0005 Information Dengue Virus Aptamer ATW0064 Information
Erk1 (aa190-208) Aptamer, ATW0091 Data Sheet Product Page pErk1, Thr202 (aa190-208) Aptamer, ATW0092 Data Sheet Product Page pErk2, Thr183 (aa171-189) Aptamer, ATW0090 Data Sheet Product Page
Hemoglobin (Human) Aptamer, ATW0010 Data Sheet Product Page Hemoglobin (Human) Aptamer, ATW0011 Data Sheet Product Page
IL-6 (Human) Aptamer ATW0035 Information IL-6 (Murine) Aptamer, ATW0077 Data Sheet Product Page IL-6 (Murine) Aptamer, ATW0082 Data Sheet Product Page IL-6 (Murine) Aptamer, ATW0083 Data Sheet Product Page
Latency Associated Peptide, LAP (Human), ATW0025 Data Sheet Product Page Latency Associated Peptide, LAP (Human), ATW0026 Data Sheet Product Page
MMP-3 (Murine) Aptamer, ATW0062 Data Sheet Product Page MMP-3 (Murine) Aptamer, ATW0063 Data Sheet Product Page
MRSA Aptamer ATW0033 Information
p24, HIV-1 Aptamer, ATW0038 Data Sheet Product Page p24, HIV-1 Aptamer, ATW0041 Data Sheet Product Page
Penicillin-binding-protein 2a, PBP2a, from MRSA, ATW0032 Data Sheet Product Page Penicillin-binding-protein 2a, PBP2a, from MRSA, ATW0033 Data Sheet Product Page
Tetanus Toxoid Aptamer, ATW0073 Data Sheet Product Page Tetanus Toxoid Aptamer, ATW0074 Data Sheet Product Page