New Base Pair Publication: Inhibition of Vitamin C Oxidation by DNA Aptamers
Base Pair has discovered an aptamer that inhibits the oxidation of vitamin C. The initial aptamer reduced vitamin C oxidation 2-fold to 4-fold under oxidizing conditions. Preliminary results suggest the potential for aptamers as stabilizers of key ingredients in beverages, nutritional supplements, and cosmetics. View Article PDF
DNA Aptamers or RNA Aptamers?
A growing number of researchers are turning to custom aptamer selection for detection of difficult targets, including small molecules and toxic compounds, and selective detection of highly similar compounds, but is it better to select for DNA aptamers or RNA Aptamers? Visit DNA Aptamers or RNA Aptamers? to learn more.
Enhancing Aptamer Stability
Stability can be of great concern when designing reagents for in vivo applications or blood-based tests. Several aptamer modifications have proven successful in extending aptamer half-life. Visit Enhancing Aptamer Stability to learn more.
The Importance of Negative Aptamer Selection
While the target is a critical component of any aptamer selection, negative targets, or molecules the aptamer SHOULD NOT bind, can be critically important as well. Incorporating negative targets into the selection design can generate more selective aptamers more quickly. Visit the Negative Aptamer Selection page to learn more.
Bill Jackson Ph.D. discusses aptamers and aptamer selection, the differences between aptamers and antibodies, aptamer advantages, aptamer development at Base Pair, and data for a wide range of aptamer-based applications in research, diagnostics, and therapeutics.
Thank you to our recent Base Pair Biotechnologies Aptamer Survey winners from: Philadelphia, PA, USA San Diego, CA, USA Ontario, Canada
Bill Jackson Ph.D. and CSO at Base Pair Biotechnologies was interviewed for an article in International Innovation, Health Partnership, the leading global dissemination resource for the wider scientific, technology and research communities. The article entitled “Apt Aptamer Technology” on page 100 of the August 2013 issue explores how aptamers are proving an effective alternative to conventional immunization and information on Base Pair’s patented approach to custom aptamer development.
Aptamer Handling & Storage
Specific buffers and re-folding procedures are recommended for optimal aptamer stability and performance. Download the Aptamer Best Practices: Handling & Storage Guide to learn more.