Matrix metalloproteinase-3, also called Stromelysin-1, is an enzyme that degrades fibronectin, laminin, gelatins, collagens, and cartilage proteoglycans. Elevation of MMP-3 has been linked to metastatic osteosarcoma. There are currently two DNA aptamers to mouse MMP-3 available from Base Pair.
Huang, J.F. et al. (2016) Elevated expressiopn of matrix metalloproteinase-3 in human osteosarcoma and its association with tumor metastasis. J. BUON. 21(1):235-43.