7.24.12-We have published a new Tech Note exploring Microscale Thermophoresis (MST) for characterizing the aptamer:target dissociation constant (Kd) of our small molecule specific aptamers. Our discovery services include validation of aptamer binding by Kd before delivery of aptamer materials to the customer for further testing. Analytical methods such as Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) are typically used for larger targets. Recently, however, we have explored and validated MST developed by NanoTemper Technologies GmbH (Munchen, Germany). In the case of aptamers to small molecules, MST has no lower molecular weight limit and can therefore “see” into a range that SPR and BLI cannot. NanoTemper Technologies GmbH develops, produces and markets innovative, high quality instruments for bio-medical research based on NanoTemper’s unique and proprietary MST technology. The newest Note is Binding Analytics of an Aptamer to Small Molecule Determined by Microscale Thermophoresis.