We are pleased that you are considering aptamers and thank you for considering Base Pair Biotechnologies as your aptamer discovery/development partner. Our entire team is committed to discovering and developing the best possible aptamer-based solutions for you. Below are a few of the reasons why Base Pair should be your go-to partner for aptamer discovery and development.
Before beginning any project or preparing a quote, Base Pair scientists take the time to consult with you to fully understand your needs, objectives, and requirements. Our Chief Scientist and Aptamer Development Manager are personally involved in the design of all aptamer discovery and development projects. We carefully review project goals, research the chemical and biological properties of your targets and the characteristics of your desired applications for the aptamers, and identify potential technical challenges. We design strategies for overcoming those challenges. Our exclusive AptaTracker™ platform provides direct communication between you and our Base Pair scientists throughout each project.
At Base Pair, we know that any one strategy is not necessarily ideal for all aptamer discovery and development projects. In each case, we choose from our portfolio of proprietary aptamer libraries or design a specialized library to match the characteristics of your target(s) and end use application. We consider multiple SELEX™ configurations, numerous potential aptamer modifications, and specialized characterization methods for the aptamer candidates. Our goal is to design the best possible approach for each individual project to create aptamers that meet your unique needs.
Base Pair scientists are continually improving on current aptamer selection, optimization, and characterization methods. Base Pair’s proprietary multiplex SELEX™ method enables simultaneous selection of aptamers for up to 30 targets, saving significant time and cost and enabling true competitive binding during the selection process. Our data analysts apply proprietary algorithms to identify the best aptamer candidates. Research into new methods for improving aptamer selection and characterization is always underway.
Base Pair scientists understand that true success is defined by aptamer performance in real-world applications. We carefully select aptamers under end-use conditions to ensure compatibility. Base Pair scientists have extensive experience in assay development and have optimized aptamer-specific procedures for use in multiple applications.
Small Molecule Experience
Aptamers are unique in their ability to selectively recognize non-immunogenic and/or toxic small molecules. Base Pair has successfully developed aptamers to multiple small molecules for use in applications as varied as point of care tests for drugs of abuse, important metabolites, environmental contaminants, and chemical defense agents. We utilize proprietary methods to solubilize and present small molecules for aptamer selection and to accurately measure the affinity of aptamers for binding to small molecule targets.
Commercial Use Rights
The Base Pair team is here to guide you through the challenges and pitfalls of managing aptamer sequences, intellectual property, and patents. We work closely with you throughout the aptamer discovery and development process to ensure your research and business interests are carefully protected, and once that process is complete, to provide you with the rights you need to be successful in a competitive marketplace.