Antibodies and aptamers exhibit selective affinity that can be used for detection and targeting of specific receptors, ligands, and other targets of interest. While antibody and aptamer affinity reagents can be used in many of the same applications, differences in development, physical characteristics, and production create some specific aptamer advantages. Aptamers are proving to be a simple solution for applications that cannot rely on traditional antibodies. This review of antibodies vs. aptamers will touch on several topics, including:

  • Antibody Development 
  • Aptamer Development 
  • Access to Tissues and Cells
  • Immunogenicity
  • Specificity / Selectivity
  • Interfering Antibodies
  • Production of Antibodies and Aptamers
  • Stability and Long-term Access

Ab vs aptamer size

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