ATW0003 - αB Crystallin Aptamer

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Target:   Crystallin alpha B

Target Species:   human

Target Type:   protein

Affinity Constant (Kd):   152 nM

Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.

*Please note that aptamers have much lower molecular weights than antibodies. Thus, there are typically five to fifteen times as many moles or molecules of aptamers present in a solution containing an equal mass. For example, 100 micrograms of an aptamer is equivalent to 0.5 to 1.5 mg of antibody, depending on the particular aptamer.

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ATW0003 Aptamer to Human αB Crystallin. Crystallins are composed of two gene products; alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein(sHSP also known as the HSP20). They act as molecular chaperones and hold them in in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional function of '-crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-B is expressed widely in many tissues and organs and occurs in many neurological diseases. This aptamer was selected by scientists at Base Pair Biotechnologies using proprietary methods and Crystallin AB, Novus Biologicals [Cat #NBC1-18352]• as a target.

Crystallin AB ATW0003 #347 datasheet [Download]