ATW0012 Aptamer to Murine Heparan Sulfate Proteoglycan, HS. Heparan Sulfate Proteoglycan, HS, is an integral part of the basement membrane. It is a large biomolecule with a molecular mass >400 kDa composed of a core protein covalently bound to heparin sulfate chains. It is a component of the extracellular matrix that binds to fibroblast growth factors, vascular endothelial growth factor, VEGF, and VEGF receptors through its sugar moiety. It acts as a docking molecule for matrilysin, MMP-7, and other matrix metalloproteinases. It may be important in cell proliferation and differentiation. This aptamer was selected by scientists at Base Pair Biotechnologies using proprietary methods and murine sarcoma basement membrane Heparin Sulfate Proteoglycan, Sigma Part No. H4777, as a target.