ATW0012 - Heparan Sulfate Proteoglycan (HS) Aptamer

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Target:   Heparin Sulfate Proteoglycan

Target Species:   murine

Target Type:   protein

Affinity Constant (Kd):   7.3 nM

Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.

*Please note that aptamers have much lower molecular weights than antibodies. Thus, there are typically five to fifteen times as many moles or molecules of aptamers present in a solution containing an equal mass. For example, 100 micrograms of an aptamer is equivalent to 0.5 to 1.5 mg of antibody, depending on the particular aptamer.

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ATW0012 Aptamer to Murine Heparan Sulfate Proteoglycan, HS. Heparan Sulfate Proteoglycan, HS, is an integral part of the basement membrane. It is a large biomolecule with a molecular mass >400 kDa composed of a core protein covalently bound to heparin sulfate chains. It is a component of the extracellular matrix that binds to fibroblast growth factors, vascular endothelial growth factor, VEGF, and VEGF receptors through its sugar moiety. It acts as a docking molecule for matrilysin, MMP-7, and other matrix metalloproteinases. It may be important in cell proliferation and differentiation. This aptamer was selected by scientists at Base Pair Biotechnologies using proprietary methods and murine sarcoma basement membrane Heparin Sulfate Proteoglycan, Sigma Part No. H4777, as a target.

Heparin Sulfate• ATW0012 #202 datasheet [Download]