ATW0021 - Human Immunoglobulin M (IgM) mu chain Aptamer

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Target:   IgM (Immunoglobulin M)

Target Species:   human

Target Type:   antibody

Affinity Constant (Kd):   178 pM

Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.

*Please note that aptamers have much lower molecular weights than antibodies. Thus, there are typically five to fifteen times as many moles or molecules of aptamers present in a solution containing an equal mass. For example, 100 micrograms of an aptamer is equivalent to 0.5 to 1.5 mg of antibody, depending on the particular aptamer.

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Image courtesy of Oklahoma Medical Research Foundation

ATW0021 Aptamer to Human IgM mu Chain Plasma Protein

Immunoglobulin M, or IgM for short, is a basic antibody that is produced by B cells. IgM is by far the physically largest antibody in the human circulatory system. It is the first antibody to appear in response to initial exposure to antigen. Immunoglobulins are made up of two heavy and two light chains and heavy chains define the isotype. Amino acid sequence determines the type of heavy chain, Immunoglobulin G has gamma heavy chains and IgM has mu heavy chains. IgM forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, mostly as a pentamer but also as a hexamer.

This aptamer was selected by scientists at Base Pair Biotechnologies using proprietary methods and IgM mu chain plasma protein, [Athens Research Cat# 16-16-090713-MU]

IgM mu ATW0021 #262 datasheet [Download]