ATW0025 - Latency Associated Peptide (LAP) Aptamer

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Target:   LAP / TGF beta 1 Complex (Latency Associated Peptide, Transforming Growth Factor Beta 1)

Target Species:   human

Target Type:   protein

Affinity Constant (Kd):   5.6 nM

Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.

*Please note that aptamers have much lower molecular weights than antibodies. Thus, there are typically five to fifteen times as many moles or molecules of aptamers present in a solution containing an equal mass. For example, 100 micrograms of an aptamer is equivalent to 0.5 to 1.5 mg of antibody, depending on the particular aptamer.

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ATW0025 Aptamer to Human Latency Associated Peptide (LAP)• TGF-beta is secreted by many cell types, including macrophages, in a latent form in which it is complexed with two other polypeptides, latent TGF-beta binding protein (LTBP) and latency associated peptide (LAP). Serum proteinases such as plasmin catalyze the release of active TGF-beta from the complex. This often occurs on the surface of macrophages where the latent TGF-beta complex is bound to CD36 via its ligand, thrombospondin-1 (TSP-1). This aptamer was selected by scientists at Base Pair Biotechnologies using proprietary methods and recombinant• Latency Associated Peptide (LAP), [R&D Systems, Cat# 246-LP/CF]• as a target.

ATW0025 LAP Data Sheet [Download]