ATW0032 - MRSA PBP-2a Aptamer

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Target:   PBP-2a, Penicillin-binding-protein 2a from Staphylococcus aureus

Target Species:   bacterial

Target Type:   protein

Affinity Constant (Kd):   2 nM

Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.

*Please note that aptamers have much lower molecular weights than antibodies. Thus, there are typically five to fifteen times as many moles or molecules of aptamers present in a solution containing an equal mass. For example, 100 micrograms of an aptamer is equivalent to 0.5 to 1.5 mg of antibody, depending on the particular aptamer.

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Image courtesy of CDC/Matthew J. Arduino, DRPH, Photo credit: Janice Haney Carr

ATW0032 Aptamer to MRSA Penicillin-Binding-Protein 2a Bacterial Protein

Methicillin-resistant Staphylococcus aureus, abbreviated MRSA, is one of a number of greatly feared strains of S. aureus which have become resistant to most B lactam antibiotics. Resistance is conferred by the mecA gene, which codes for an altered penicillin-binding protein (PBP2a or PBP2') that has a lower affinity for binding B lactams (penicillins, cephalosporins, and carbapenems). This allows for resistance to all B lactam antibiotics, and obviates their clinical use during MRSA infections.

This aptamer was selected by scientists at Base Pair Biotechnologies using proprietary methods and Recombinant Staphylococcus aureus PBP2a, [Ray Biotech Cat # 230-00051] as a target.

View MRSA Aptamer ATW0032 Data Sheet

ATW0032 MRSA Aptamer Data Sheet [Download]

ELISA data ATW0032 [Download]