ATW0033 - MRSA PBP-2a Aptamer

ATW0033
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Target:   PBP-2a, Penicillin-binding-protein 2a from Staphylococcus aureus

Target Species:   bacterial

Target Type:   protein

Affinity Constant (Kd):   23.5 nM

Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.

*Please note that aptamers have much lower molecular weights than antibodies. Thus, there are typically five to fifteen times as many moles or molecules of aptamers present in a solution containing an equal mass. For example, 100 micrograms of an aptamer is equivalent to 0.5 to 1.5 mg of antibody, depending on the particular aptamer.

Base Pair Biotechnologies, Inc. does not collect VAT, import taxes, tariffs, duties, or other taxes, which are the sole responsibility of the purchaser.

Image courtesy of CDC/Matthew J. Arduino, DRPH, Photo credit: Janice Haney Carr

ATW0033 Aptamer to MRSA PBP-2a Bacterial Protein

Methicillin-resistant Staphylococcus aureus, abbreviated MRSA, is one of a number of greatly feared strains of S. aureus which have become resistant to most B lactam antibiotics. Resistance is conferred by the mecA gene, which codes for an altered penicillin-binding protein (PBP2a or PBP2') that has a lower affinity for binding B lactams (penicillins,cephalosporins, and carbapenems). This allows for resistance to all B lactam antibiotics, and obviates their clinical use during MRSA infections.

This aptamer was selected by scientists at Base Pair Biotechnologies using proprietary methods and Recombinant Staphylococcus aureus PBP2a, [Ray Biotech Cat # 230-00051] as a target.

View MRSA Aptamer ATW0033 Data Sheet

ATW0033 MRSA Aptamer Data Sheet [Download]