ATW0035 - IL-6 Aptamer

ATW0035
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Target:   IL-6 (Interleukin-6)

Target Species:   human

Target Type:   protein

Affinity Constant (Kd):   19 nM

Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.

*Please note that aptamers have much lower molecular weights than antibodies. Thus, there are typically five to fifteen times as many moles or molecules of aptamers present in a solution containing an equal mass. For example, 100 micrograms of an aptamer is equivalent to 0.5 to 1.5 mg of antibody, depending on the particular aptamer.

Base Pair Biotechnologies, Inc. does not collect VAT, import taxes, tariffs, duties, or other taxes, which are the sole responsibility of the purchaser.

Image courtesy of Ramin Herati

ATW0035 Aptamer to Human Interleukin-6 (IL-6) Cytokine

Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response and is also considered a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. During exercise, it is thought to act in a hormone-like manner to mobilize extracellular substrates and/or augment substrate delivery. Additionally, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF alpha and IL-1, and activation of IL-1ra and IL-10.

This aptamer was selected by scientists at Base Pair Biotechnologies using proprietary methods, recombinant Human Interleukin-6, [R&D Systems, Cat #206-IL-050]

View IL-6 Aptamer Data Sheet

ATW0035 IL-6 Aptamer Data Sheet [Download]