ATW0044 Aptamer to Human Cytomegalovirus gB (CMV gB) Viral Protein
Human cytomegalovirus(CMV) (human herpesvirus 5) glycoprotein B is a 907-amino acid glycoprotein encoded by the ORF of UL55. It is the most abundant component of the envelope with at least two defined neutralizing epitopes, a target of neutralizing antibodies and an essential replication component. gB plays important roles in HCMV entry, cell-cell spread of internal virions, and fusion of infected cells. It triggers penetration of cells and enhances the spread of infection in nonpolarized human fibroblasts
This aptamer was selected by scientists at Base Pair Biotechnologies using proprietary methods and human CMV gB, [Sino Biological Inc., Cat #10202-V08H1] as a target