Human cytomegalovirus, HCMV, is a herpesvirus that infects between 50 to 85% of adults by the age of 50. Though most people do not show symptoms of disease, HCMV is a major cause of morbidity in AIDS and organ transplant. There is currently no vaccine and no cure for HCMV. Pp65 is the primary protein invlolved in evasion of host immune response in HCMV infection. It has been shown to prevent recognition by the immune system, to interfere with synthesis of immune components, and to inhibit natural killer cell cytotoxicity.
John Paul Tomtishen III, (2012) Human cytomegalovirus tegument proteins (pp65, pp71, pp150, pp28). Virology Journal. 9:22.