CD45, also called lymphocyte common antigen, is a membrane glycoprotein. The intracellular region has protein tyrisine phosphatase activity. CD45 is involved in hematopoietic cell differentiation and T cell activation.
Altin, J.G., et al. (1997) The role of CD45 and CD45-associated molecules in T cell activation. Immunol. Cell. Biol. 75(5):430-45. and Nakano, A. et al. (1990) Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines. Acta. Pathol. Jpn. 40(2):107-15.