Zika virus is a mosquito-borne flavivirus. It is transmitted by the Aedes mosquito, which also transmits Dengue, Chikungunya, and yellow fever. Contraction of Zika during pregnancy can cause microcephaly and other abnormalities in newborns as well as fetal loss, stillbirth, and pre-term birth. Zika infection has also been linked to Guillain-Barre syndrome, neuropathy, and myelitis (1). These DNA aptamers were selected against the Zika envelope protein in mosquito saliva, but have also been shown to bind the Zika envelope protein in serum and defibrinated blood (2).
- WHO. https://www.who.int/news-room/fact-sheets/detail/zika-virus. Accessed May 15, 2019.
- Saraf, N., et al. Multiplex viral detection platform based on a aptamers-integrated microfluidic channel. ACS Omega. 2019. 4:2234-2240. https://pubs.acs.org/doi/10.1021/acsomega.8b03277