Why Aptamers?
Aptamers offer solutions to many scientific challenges other reagents can’t overcome. Learn More.
Pursue Toxic and Non-immunogenic Targets
Overcome antibody host toxicity or failure to generate an antibody responseTarget Small Molecules
Bind molecules ≥ ~60 daltons, 10-fold smaller than the smallest Ab targetsDesign Stable Molecular “Switches”
Simplify assay design or modulate therapeutic functionPenetrate Tissues and Cells
Target intracellular proteins; access solid tumorsPerform Simple Chemical Modifications
Enhance affinity, stability, solubility or detectionImprove Reproducibility and Stability
Easily synthesize and re-fold aptamersPartnering with Base Pair
Every project is unique. Base Pair scientists work closely with each client to understand project objectives, identify technical challenges, and provide innovative aptamer-based solutions. Learn More.
Consultative Approach
We take the time to fully understand customer needs and address project challenges
Customized Solutions
Every project is carefully designed from classic and novel options for selection and optimization
Innovative Technology
Multiplex SELEX™ , proprietary selection algorithms and characterization techniques
Effective Aptamers
True success is defined by aptamer performance in real-world applications
Aptamer Discovery and Development with Base Pair
At Base Pair, each phase of every project is designed to have the highest likelihood of functional success. Learn More
Phase 1: Consult
Needs DefinitionProject Scope
Phase 2: Design
Library SelectionLibrary Modification
Target Selection
Phase 3: Select
SELEXNext Gen Sequencing
Bioinformatics
Phase 4: Screen
High Throughput ScreeningBioinformatics
Affinity Testing
Phase 5: Apply & Evaluate
Assay FeasibilityFunctional Testing
Assay Optimization
Phase 6: Mature
TruncationBase Substitution
New Functionality
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Let Base Pair design an aptamer selection strategy for your application.